Shargel and Yu's applied biopharmaceutics and pharmacokinetics / Editors Murray P. Ducharme and Leon Shargel

Part I: Introduction to Biopharmaceutics and Pharmacokinetics
Chapter 1: Introduction to Biopharmaceutics and Pharmacokinetics
Chapter 2: Mathematical Fundamentals in Pharmacokinetics
Chapter 3: Biostatistics

Part II: Fundamentals of Biopharmaceutics
Chapter 4: Physiologic Factors Related to Drug Absorption
Chapter 5: Drug Distribution and Protein Binding
Chapter 6: Physiology of Drug Elimination
Chapter 7: Biopharmaceutic Considerations in Drug Product Design and In Vitro Drug Product Performance
Chapter 8: Drug Product Performance, In Vivo: Bioavailability and Bioequivalence
Chapter 9: Modified-Release Drug Products and Drug Devices
Chapter 10: Targeted Drug Delivery Systems and Biotechnology Products

Part III: Pharmacokinetic Principles
Chapter 11: Introduction to Pharmacokinetic and Pharmacodynamic Models and Analyses
Chapter 12: One-Compartment Open Model: Intravenous Bolus Administration
Chapter 13: Multicompartment Models: Intravenous Bolus Administration
Chapter 14: Intravenous Infusion
Chapter 15: Pharmacokinetic Calculations for Drug Elimination and Clearance
Chapter 16: Pharmacokinetics of Drug Absorption
Chapter 17: Multiple-Dosage Regimens
Chapter 18: Nonlinear Pharmacokinetics
Chapter 19: Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental PK/PD Analyses
Chapter 20: Applications of Software Packages in Pharmacokinetics

Part IV: Pharmacodynamics and Clinical Pharmacokinetics
Chapter 21: Pharmacogenetics, Drug Metabolism, Transporters, and Individualization of Drug Therapy
Chapter 22: Relationship between Pharmacokinetics and Pharmacodynamics
Chapter 23: Application of Pharmacokinetics to Clinical Situations
Chapter 24: Application of Pharmacokinetics and Pharmacodynamics to Aging, Obese, and Pediatric Patients
Chapter 25: Dose Adjustment in Renal and Hepatic Diseases

Part V: Biopharmaceutics and Pharmacokinetics in Drug Product Development
Chapter 26: Biopharmaceutical Aspects of the Active Pharmaceutical Ingredient and Pharmaceutical Equivalence
Chapter 27: Rational Drug Product Development, Quality, and Performance
Chapter 28: FDA-Approved Novel Dosage Forms
Chapter 29: Clinical Development and Therapeutic Equivalence of Generic Drugs and Biosimilar Products
Chapter 30: Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development

Includes bibliographical references and index